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In primary rat pituitary cell culture, TNF-α can induce a rapid increase in intracellular free calcium concentration, and the time course is highly consistent with the increase in prolactin secretion, suggesting that the calcium signaling pathway plays a key downstream effect in the process of inflammatory factors directly acting on prolactin-secreting cells

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Armed with more insight, labs could engineer peptides that target the cells that make AMH or help the ovaries age slower